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Published on: February 12, 2021
Development and application of a solution-phase automated synthesizer, 'ChemKonzert'
Kazuhiro Machida1, Yoichiro Hirose, Shinichiro Fuse
1Development Department, ChemGenesis Incorporated, Tokyo, Japan. kmachida@chemgenesis.com
Abstract:
In this paper we describe the development of a fully-automated solution-phase synthesizer, 'ChemKonzert' that can be used to prepare a wide variety of organic compounds. The automated synthesizer is ingeniously designed to perform most of the chemical reactions currently used by synthetic organic chemists and utilizes a centrifugal separator to efficiently achieve liquid-liquid extraction. The design of the hardware and software will be described in this paper, and several examples of organic reactions will also be presented as applications of the apparatus.
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