Discovery of anticancer agents of diverse natural origin
A Douglas Kinghorn1, Esperanza J Carcache de Blanco, Hee-Byung Chai
1College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Abstract:
A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.
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