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Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
Centrifugation01:05

Centrifugation

Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...

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Related Experiment Video

Updated: Jun 17, 2026

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
10:27

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

Cell Separation by Non-Inertial Force Fields in Microfluidic Systems.

Hideaki Tsutsui1, Chih-Ming Ho

  • 1Mechanical and Aerospace Engineering Department, University of California, Los Angeles, Los Angeles, CA 90095, United States.

Mechanics Research Communications
|January 5, 2010
PubMed
Summary
This summary is machine-generated.

Microfluidic separation uses forces to sort cells and microparticles for biological studies. This review covers non-inertial forces like dielectrophoretic and acoustic forces for advanced sample preparation.

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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

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Last Updated: Jun 17, 2026

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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Area of Science:

  • Biotechnology
  • Microfluidics
  • Analytical Chemistry

Background:

  • Microfluidic systems are crucial for biological and chemical sample preparation.
  • Effective cell and microparticle separation is key in these systems.
  • Differential forces are commonly used to achieve particle separation.

Purpose of the Study:

  • To review fundamental concepts and innovative designs of microfluidic separators.
  • To emphasize the application of non-inertial force fields in microfluidic separation.
  • To provide a reference for selecting appropriate separation methods for diverse applications.

Main Methods:

  • Review of microfluidic separation techniques.
  • Focus on non-inertial force fields: dielectrophoretic, optical gradient, magnetic, and acoustic forces.
  • Comparison of separation performance metrics.

Main Results:

  • Detailed overview of microfluidic separator designs utilizing non-inertial forces.
  • Analysis of the effectiveness of dielectrophoretic, optical, magnetic, and acoustic forces for separation.
  • Discussion of physiological effects and instrumentation for point-of-care applications.

Conclusions:

  • Non-inertial force fields offer versatile methods for microfluidic cell and microparticle separation.
  • Understanding force field characteristics is vital for optimizing separation performance.
  • The review provides insights for developing advanced point-of-care diagnostic devices.