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Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Evaluating functional decline in patients with Multiple Sclerosis.

Sara Rosenblum¹, Patrice L Tamar Weiss

¹Department of Occupational Therapy, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa, Israel. rosens@research.haifa.ac.il

Research in Developmental Disabilities

|January 6, 2010

Summary

This summary is machine-generated.

Evaluating fatigue, daily activities, and handwriting can help identify functional decline in Multiple Sclerosis (MS) patients. Combining these assessments accurately identified 87.7% of participants, aiding in targeted interventions.

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Assessing Functional Performance in the Mdx Mouse Model

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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

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Published on: January 29, 2016

Area of Science:

Neurology
Rehabilitation Medicine
Biomedical Engineering

Background:

Multiple Sclerosis (MS) significantly impacts patients' functional status.
Early identification of functional decline is crucial for effective management.

Purpose of the Study:

To assess the combined value of fatigue, personal Activities of Daily Living (ADL), and handwriting performance in detecting functional decline in MS.
To explore objective measures for evaluating functional status in MS patients.

Main Methods:

Study included 50 MS outpatients and 26 healthy controls.
Utilized the Fatigue Severity Scale (FSS), Physical Self-Maintenance Scale (PSMS), and computerized handwriting analysis (ComPET).
Compared outcomes between MS patients and controls.

Main Results:

MS patients exhibited significantly higher fatigue levels, lower PSMS scores, and altered handwriting (increased in-air time per stroke) compared to controls.
A model integrating FSS, specific PSMS items, and handwriting measures achieved 87.7% correct classification of participants.
Demonstrated the added value of combining body function (fatigue) and activity performance (ADL, handwriting) measures.

Conclusions:

Simultaneous evaluation of fatigue, ADL, and handwriting offers valuable insights into functional decline in MS.
These findings support the development of targeted interventions to improve performance and quality of life for MS patients.