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Updated: Jun 17, 2026

Simultaneous Measurements of Intracellular Calcium and Membrane Potential in Freshly Isolated and Intact Mouse Cerebral Endothelium
Published on: January 20, 2019
[Calcium antagonists: current and future applications based on new evidence. Pleiotropic effects of calcium channel
Yasutsugu Morimoto1, Yasuko Kureishi-Bando, Toyoaki Murohara
1Department of Cardiology, Nagoya University Graduate School of Medicine.
Abstract:
Ample evidence has demonstrated that calcium channel blockers (CCBs) exert pleiotropic effects on vasculature, leading to restoring endothelial dysfunction and suppressing progression of atherosclerosis both in experimental and clinical settings. CCBs protect vasculature by various antioxidative mechanisms as follows : stimulating endothelial NO production and/or restoring decline in circulating adiponectin and HDL level. Moreover, CCBs has been also demonstrated to enhance circulating endothelial progenitor cell level, of which has been known to correlate to endothelial function. through its antioxidative property. Accordingly, these evidences suggest that CCB could be expected as another antiatherosclerotic remedy in patient population.
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