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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Updated: Jun 17, 2026

Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device
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Published on: November 10, 2023

Nanoparticle therapeutics: a personal perspective.

Scott E McNeil1

  • 1Nanotechnology Characterization Lab, Imaging and Nanotechnology Group, SAIC-Frederick Inc./National Cancer Institute at Frederick, MD, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|January 6, 2010
PubMed
Summary
This summary is machine-generated.

Nanotechnology in cancer research offers improved drug efficacy and reduced toxicity. Challenges in nanoparticle characterization and scale-up are being addressed for advanced cancer therapeutics and diagnostics.

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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
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Published on: March 4, 2017

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Last Updated: Jun 17, 2026

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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Area of Science:

  • Oncology
  • Materials Science
  • Biotechnology

Background:

  • Nanotechnology presents significant opportunities for advancing cancer research, including targeted drug delivery and novel therapeutic strategies.
  • The application of nanotechnology in medicine (nanomedicine) aims to improve solubility, bioavailability, and therapeutic efficacy of cancer treatments.
  • Engineered nanoparticles are being developed for both cancer therapeutics and diagnostics.

Purpose of the Study:

  • To review the challenges and benefits of utilizing nanotechnology in cancer research.
  • To discuss the complexities in preclinical characterization of nanoparticles for in vivo studies.
  • To highlight the advancements and ongoing clinical trials in nanomedicine for oncology.

Main Methods:

  • Review of current literature on nanotechnology applications in cancer research.
  • Analysis of challenges in nanoparticle material characterization, surface properties, and reactivity.
  • Examination of in vivo tracking of multicomponent nanoparticle therapeutics.
  • Consideration of regulatory and scale-up challenges in nanomedicine development.

Main Results:

  • Nanoparticle formulations have demonstrated improved efficacy and reduced toxicity of chemotherapeutics.
  • Several engineered nanoparticle-based cancer therapies are progressing through clinical trials.
  • Nanotechnology enables passive and active targeting strategies for cancer treatment.
  • Advancements in nanoparticle design offer potential for enhanced drug delivery and diagnostic capabilities.

Conclusions:

  • Despite characterization and scale-up hurdles, nanomedicine holds immense promise for improving cancer treatment outcomes.
  • Nanotechnology is revolutionizing cancer diagnostics and therapeutics, leading to more effective and less toxic therapies.
  • Continued research and development in nanomedicine are crucial for overcoming existing challenges and realizing its full potential in oncology.