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Updated: Jun 17, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Cell-targeting and cell-penetrating peptides for delivery of therapeutic and imaging agents
Rudolph L Juliano1, Rowshon Alam, Vidula Dixit
1Department of Pharmacology, University of North Carolina, Chapel Hill, USA. arjay@med.unc.edu
Abstract:
This review will discuss the basic concepts concerning the use of cell-targeting peptides (CTPs) and cell-penetrating peptides (CPPs) in the context of nanocarrier technology. It deals with the discovery and subsequent evolution of CTPs and CPPs, issues concerning their interactions with cells and their biodistribution in vivo, and their potential advantages and disadvantages as delivery agents. The article also briefly discusses several specific examples of the use of CTPs or CPPs to assist in the delivery of nanoparticles, liposomes, and other nanocarriers.
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