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Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

The PediPump: a versatile, implantable pediatric ventricular assist device--update IV

Brian W Duncan1, Kiyotaka Fukamachi, Lawrence D Noble

  • 1The Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. duncanb@ccf.org

Artificial Organs
|January 6, 2010
PubMed

Insights

Cleveland Clinic developed the PediPump, a pediatric ventricular assist device. Preclinical trials in sheep show excellent hemodynamic performance and minimal hemolysis, indicating readiness for clinical testing.

Area of Science:

  • Biomedical Engineering
  • Pediatric Cardiology

Background:

  • Pediatric heart failure requires innovative circulatory support solutions.
  • Existing ventricular assist devices (VADs) may not be optimally sized or designed for pediatric patients.

Purpose of the Study:

  • To report on the development and preclinical evaluation of the PediPump, a novel VAD for pediatric use.
  • To assess the engineering advancements, anatomical modeling capabilities, and in vivo performance of the PediPump.

Main Methods:

  • Iterative design improvements focusing on miniaturization, motor, magnetic bearings, and heat transfer.
  • Development of 3D anatomical modeling and device-fitting tools using CT and MRI data.
  • In vivo testing in sheep, including acute (6-hour) and chronic (30-day) implantations.

Main Results:

  • The PediPump incorporates significant engineering enhancements for size reduction and improved function.
  • Anatomical modeling facilitates preoperative planning and device implantation.
  • Sheep studies demonstrated easy implantation, excellent hemodynamics, and minimal hemolysis.

Conclusions:

  • The PediPump represents a significant advancement in pediatric ventricular assist device technology.
  • Preclinical evaluation indicates satisfactory performance and readiness for clinical trials.

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