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Updated: Jun 17, 2026
06:10
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Published on: June 12, 2021
The PediPump: a versatile, implantable pediatric ventricular assist device--update IV
Brian W Duncan1, Kiyotaka Fukamachi, Lawrence D Noble
1The Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. duncanb@ccf.org
Artificial Organs
|January 6, 2010
Summary
Cleveland Clinic developed the PediPump, a pediatric ventricular assist device. Preclinical trials in sheep show excellent hemodynamic performance and minimal hemolysis, indicating readiness for clinical testing.
Area of Science:
- Biomedical Engineering
- Pediatric Cardiology
Background:
- Pediatric heart failure requires innovative circulatory support solutions.
- Existing ventricular assist devices (VADs) may not be optimally sized or designed for pediatric patients.
Purpose of the Study:
- To report on the development and preclinical evaluation of the PediPump, a novel VAD for pediatric use.
- To assess the engineering advancements, anatomical modeling capabilities, and in vivo performance of the PediPump.
Main Methods:
- Iterative design improvements focusing on miniaturization, motor, magnetic bearings, and heat transfer.
- Development of 3D anatomical modeling and device-fitting tools using CT and MRI data.
- In vivo testing in sheep, including acute (6-hour) and chronic (30-day) implantations.
Main Results:
- The PediPump incorporates significant engineering enhancements for size reduction and improved function.
- Anatomical modeling facilitates preoperative planning and device implantation.
- Sheep studies demonstrated easy implantation, excellent hemodynamics, and minimal hemolysis.
Conclusions:
- The PediPump represents a significant advancement in pediatric ventricular assist device technology.
- Preclinical evaluation indicates satisfactory performance and readiness for clinical trials.
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