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Updated: Jun 17, 2026
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Different approaches for determination of the attachment degree of polyethylene glycols to poly(anhydride)
K Yoncheva1, I Doytchinova, J M Irache
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Sofia, Bulgaria. krassi.yoncheva@gmail.com
Purpose:
The aim of the study was to find an appropriate method for determination of the attachment degree of polyethylene glycol (PEG) to poly(anhydride) nanoparticles.
Methods:
The nanoparticles were modified with hydroxy-functionalized or with amino-functionalized PEGs. Three methods for their determination were applied and examined: in particular colorimetry, nuclear magnetic resonance ( (1) H-NMR), and elemental analysis (EA).
Results:
The attachment degrees determined by (1) H-NMR and colorimetry were similar. The associated amounts of PEGs estimated on the basis of EA differed significantly than those determined by colorimetry and (1) H-NMR.
Conclusion:
The colorimetric determination was considered fast and simple technique, but (1) H-NMR contributed to more precise results.
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