Related Experiment Video
Updated: Jun 17, 2026
3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
Published on: April 15, 2021
Leptin levels in gingival crevicular fluid during orthodontic tooth movement
Alparslan Dilsiz1, Nihat Kiliç, Tugba Aydin
1Department of Periodontology, Atatürk University, Erzurum, Turkey. aydilsiz@yahoo.com
Objectives:
To test if leptin can be detected in the gingival crevicular fluid (GCF) around moving teeth, and to determine whether any changes occur during orthodontic tooth movement.
Materials And Methods:
An upper canine requiring distal movement served as the test tooth; the contralateral canine was used as a control tooth. The control tooth was included in the orthodontic appliance, but was not subjected to the orthodontic force. GCF sampling from the distal sites of the test and control teeth was done at baseline, 1 hour, 24 hours, and 168 hours.
Results:
Leptin concentrations of the test teeth decreased in a time-dependent manner. When compared with the baseline measurement, the decrease was significant at 168 hours (P < .05).
Conclusions:
The concentration of leptin in GCF is decreased by orthodontic tooth movement; the results of the present study also suggest that leptin may have been one of the mediators responsible for orthodontic tooth movement.
