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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

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Related Experiment Video

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Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
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Metabolic surgery: an evolution through bariatric animal models.

H Ashrafian1, M Bueter, K Ahmed

  • 1Department of Surgery and Cancer, Imperial College, London, UK. h.ashrafian@imperial.ac.uk

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|January 7, 2010
PubMed
Summary

Metabolic surgery, developed from bariatric procedures, offers significant health benefits. Animal models provide crucial insights for advancing future metabolic operations and reducing disease risks.

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Last Updated: Jun 17, 2026

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Area of Science:

  • Metabolic surgery
  • Bariatric procedures
  • Animal models

Background:

  • Metabolic surgery evolved from bariatric procedures, with knowledge gained from animal studies.
  • Animal models have elucidated anatomical feasibility, physiological, and cellular metabolic effects of these operations.

Purpose of the Study:

  • To review the development and benefits of metabolic surgery.
  • To highlight the role of animal models in understanding metabolic operations.
  • To discuss the potential for future advancements in metabolic surgery.

Main Methods:

  • Review of historical and current metabolic/bariatric surgical procedures.
  • Analysis of insights derived from animal model studies.
  • Examination of the metabolic benefits and risk reduction associated with these surgeries.

Main Results:

  • Early procedures like jejunoileal bypass paved the way for current techniques (Roux-en-Y gastric bypass, biliopancreatic diversion, adjustable gastric banding, sleeve gastrectomy).
  • Metabolic surgery demonstrates significant benefits, including reduced risks of diabetes, heart disease, and cancer.
  • Animal models offer insights into genetic, molecular, and systemic effects crucial for future surgical development.

Conclusions:

  • Metabolic surgery has evolved significantly, offering substantial health advantages.
  • Continued research using animal models is essential for developing next-generation metabolic operations.
  • These advancements hold promise for further reducing the burden of metabolic diseases.