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Related Experiment Video

Updated: Jun 17, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Ischemic colitis related to sumatriptan overuse.

Joshua A Hodge1, Katherine D Hodge

  • 1National Capital Consortium-Dewitt Army Community Hospital, Family Medicine Residency, Ft. Belvoir, VA, USA. joshua.hodge@amedd.army.mil

Journal of the American Board of Family Medicine : JABFM
|January 7, 2010
PubMed
Summary
This summary is machine-generated.

Sumatriptan overuse can cause ischemic colitis, a serious condition. This case highlights the risk even in healthy individuals without typical risk factors, emphasizing the need for further research.

Related Experiment Videos

Last Updated: Jun 17, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Area of Science:

  • Neurology
  • Gastroenterology
  • Pharmacology

Background:

  • Serotonin-1 (5-HT 1) receptor agonists, like sumatriptan, are primary treatments for migraines.
  • Patients with difficult-to-treat migraines may exceed recommended dosages.
  • Sumatriptan overuse has been linked to ischemic colitis.

Observation:

  • A 35-year-old woman experienced severe abdominal pain without diarrhea or bloody stools.
  • She had been frequently self-treating a refractory migraine with sumatriptan.
  • Imaging and colonoscopy confirmed ischemic colitis, ruling out inflammatory bowel disease.

Findings:

  • This case involves a young, healthy patient with no prior risk factors for ischemia.
  • She is the youngest reported patient with sumatriptan-induced ischemic colitis and the first without hematochezia.
  • This challenges previous assumptions that comorbidities were solely responsible for the association.

Implications:

  • Ischemic colitis is a potential, serious adverse effect of 5-HT 1 receptor agonists.
  • Further investigation, including a retrospective review of patient data, is needed to determine the incidence of this complication.
  • Clinicians should consider ischemic colitis in patients presenting with abdominal pain after sumatriptan use.