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Related Experiment Videos

A chorionic gonadotropin-secreting human pituitary cell.

E Hammond1, J Griffin, W D Odell

  • 1Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.

The Journal of Clinical Endocrinology and Metabolism
|April 1, 1991
PubMed
Summary

Human chorionic gonadotropin (hCG) and human luteinizing hormone (hLH) are released pulsatilely, stimulated by GnRH. A novel pituitary cell type exclusively secretes hCG in nonpregnant humans.

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Area of Science:

  • Reproductive Endocrinology
  • Pituitary Physiology
  • Hormone Secretion

Background:

  • Human chorionic gonadotropin (hCG) and human luteinizing hormone (hLH) exhibit parallel pulsatile secretion in normal nonpregnant humans.
  • Gonadotropin-releasing hormone (GnRH) has been shown to stimulate the release of both hCG and hLH.

Purpose of the Study:

  • To identify the specific cell type responsible for hCG secretion in the human pituitary.
  • To characterize the morphological and immunocytochemical features of this novel cell type.

Main Methods:

  • Immunocytochemistry using a monoclonal antibody specific for the beta-chain of hCG.
  • Light microscopy and electron microscopy for ultrastructural analysis.

Main Results:

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  • Identification of a previously unknown cell type in the human pituitary that stains exclusively for hCG.
  • Detailed description of the light microscopic, immunocytochemical, and ultrastructural characteristics of these hCG-secreting cells.

Conclusions:

  • A distinct pituitary cell population is responsible for hCG secretion in normal nonpregnant humans.
  • These findings, combined with previous data, confirm the pituitary origin of hCG in nonpregnant individuals.