Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Genetic factors in bone turnover.

P J Kelly¹, J L Hopper, G T Macaskill

¹Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, NSW, Australia.

The Journal of Clinical Endocrinology and Metabolism

|April 1, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023

Same author

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022

Same author

Predictive performance of the Garvan Fracture Risk Calculator: a registry-based cohort study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021

Same author

Development and validation of the risk engine for an Australian Health Economics Model of Osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021

Same author

An independent external validation of melanoma risk prediction models using the Australian Melanoma Family Study.

The British journal of dermatology·2020

Same author

Assessing the clinical utility of genetic profiling in fracture risk prediction: a decision curve analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020

Same journal

Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge.

The Journal of clinical endocrinology and metabolism·2026

Same journal

Continuous glucose monitoring-derived time in range is associated with changes in arterial stiffness in type 2 diabetes.

The Journal of clinical endocrinology and metabolism·2026

Same journal

Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes.

The Journal of clinical endocrinology and metabolism·2026

Same journal

From Premature Adrenarche to Adult Metabolic Risk and Hyperandrogenism: A Systematic Review and Meta-Analysis.

The Journal of clinical endocrinology and metabolism·2026

Same journal

Open-Label 9-Year Follow-Up Extension Phase 2 Study of Once-Weekly Somatrogon in Children With Growth Hormone Deficiency.

The Journal of clinical endocrinology and metabolism·2026

Same journal

Correction to: "CAHQL: A Patient-Reported Outcome Instrument to Assess Health-Related Quality of Life in Congenital Adrenal Hyperplasia".

The Journal of clinical endocrinology and metabolism·2026

See all related articles

Genetic factors strongly influence bone density by regulating bone formation, as indicated by serum osteocalcin levels. This study in female twins highlights genetic control over bone turnover mechanisms.

Area of Science:

Endocrinology
Genetics
Bone Biology

Background:

Bone mineral density is influenced by genetic factors, but the mechanisms are unclear.
Bone density results from the balance between bone formation and resorption.
Biochemical markers can assess bone turnover rates.

Purpose of the Study:

To investigate the genetic mediation of bone density by examining biochemical indices of bone formation and resorption.
To determine the heritability of serum osteocalcin, urinary calcium:creatinine, and hydroxyproline:creatinine ratios in adult female twins.

Main Methods:

Studied 39 monozygotic (MZ) and 31 dizygotic (DZ) adult female twin pairs.
Measured serum osteocalcin (bone formation marker).
Measured fasting urinary calcium:creatinine (Ca/Crt) and hydroxyproline:creatinine (OH/Crt) (resorption markers).

Related Experiment Videos

Main Results:

Twin pair correlations for serum osteocalcin were significantly higher in MZ twins (r=0.81) than DZ twins (r=0.21), indicating strong genetic influence (80% variance).
In postmenopausal twins, serum osteocalcin also showed a significant genetic correlation (rMZ=0.84 vs. rDZ=-0.003).
Genetic effects on urinary Ca/Crt and OH/Crt were not demonstrable, possibly due to lower precision.

Conclusions:

Circulating osteocalcin, a marker of bone formation, is strongly genetically determined.
Genetic regulation of bone turnover, particularly bone formation, is a key mechanism underlying the genetic influence on bone mass.
Further research may clarify genetic contributions to bone resorption markers.