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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
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Published on: August 30, 2014

Ribosomal therapy in the treatment of recurrent acute adenoiditis

Renzo Mora1, Massimo Dellepiane, Barbara Crippa

  • 1ENT Department, University of Genoa, Genoa, Italy. renzomora@libero.it

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|January 7, 2010
PubMed

Insights

Oral ribosomal immunotherapy effectively manages recurrent acute adenoiditis (RAA) in children. This treatment reduced RAA episodes and improved symptoms by modulating immunoglobulin levels and enhancing nasal airflow.

Area of Science:

  • Pediatric Otolaryngology
  • Immunotherapy
  • Infectious Diseases

Background:

  • Recurrent acute adenoiditis (RAA) significantly impacts children's health and quality of life.
  • Current management strategies for RAA have limitations.
  • Ribosomal immunotherapy offers a potential novel therapeutic approach.

Purpose of the Study:

  • To evaluate the efficacy of oral ribosomal immunotherapy for managing RAA in children.
  • To assess the impact of this immunotherapy on immunological markers and clinical outcomes.

Main Methods:

  • A randomized controlled trial involving 60 children diagnosed with RAA.
  • Group A received oral ribosomal prophylaxis; Group B received a placebo.
  • Evaluations included medical history, ENT exams, immunoglobulin levels (IgE, IgA, IgG, IgM), tympanometry, rhinomanometry, and VAS scores.

Main Results:

  • The ribosomal immunotherapy group (Group A) showed significantly lower IgE levels and higher IgA and IgG titers compared to the placebo group (Group B).
  • Group A demonstrated improved tympanometry results (77% Type A vs. 23%), reduced nasal airflow resistance, and significantly lower Visual Analog Scale (VAS) scores.
  • Frequency, severity, and social impact of RAA episodes were significantly reduced in Group A compared to Group B.

Conclusions:

  • Oral ribosomal immunotherapy is an effective therapeutic strategy for the prophylaxis of recurrent acute adenoiditis in children.
  • The treatment positively influences key immunological parameters and clinical manifestations of RAA.
  • This approach offers a promising alternative for managing RAA, improving children's health outcomes.

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