Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficacy outcomes in patients using alefacept in the AWARE study.

Ian Landells1, Gordon Searles, Robert Bissonnette

  • 1Nexus Clinical Research, St. John's, NL. landells@nl.rogers.com

Journal of Cutaneous Medicine and Surgery
|January 8, 2010
PubMed
Summary

Alefacept treatment improved chronic plaque psoriasis outcomes in a real-world Canadian registry. A single course led to significant skin clearance and reduced body surface area involvement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Narrowband vs broadband ultraviolet B phototherapy for adults with moderate-to-severe atopic dermatitis: a randomized controlled trial.

The British journal of dermatology·2026
Same author

Spatially selective multiphoton photothermolysis guided by reflectance confocal microscopy for precise vessel closure in the mouse eye limbus.

Biomedical optics express·2026
Same author

GloW-VSNet: A scribble-based weakly supervised framework for global-view vitiligo lesion segmentation.

Medical image analysis·2025
Same author

Understanding the Scalp: Dandruff and Seborrheic Dermatitis.

Journal of cutaneous medicine and surgery·2025
Same author

A Canadian Consensus on Androgenetic Alopecia: Approach and Management.

Journal of cutaneous medicine and surgery·2025
Same author

Integrating Clinical Knowledge Graphs and Gradient-Based Neural Systems for Enhanced Melanoma Diagnosis via the Seven-Point Checklist.

IEEE transactions on neural networks and learning systems·2025

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Alefacept has shown efficacy in clinical trials for chronic plaque psoriasis.
  • It can be used as monotherapy or combined with other treatments like phototherapy.

Purpose of the Study:

  • To evaluate alefacept's effectiveness in a real-world setting through the AWARE registry.
  • To assess outcomes in Canadian psoriasis patients treated with alefacept.

Main Methods:

  • Observational, multicenter, phase IV Canadian registry (AWARE).
  • Patients received at least one course of alefacept, with a 12-week off-treatment period.
  • Efficacy assessed by physician/patient response at week 18 and change in body surface area (BSA) involvement.

Main Results:

Related Experiment Videos

  • 42-41% of patients achieved "cleared to marked response" by week 18.
  • 55% of patients had <10% BSA involvement at week 18, up from 20% at baseline.
  • Mean time to retreatment was 19.3 weeks for patients receiving a second course.

Conclusions:

  • A single course of alefacept improved outcomes in a broad population of chronic plaque psoriasis patients.
  • Study limitations include nonrandomized design and unvalidated rating scales.