Related Experiment Video
Updated: Jun 17, 2026
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Nanomedicine in pulmonary delivery
Heidi M Mansour1, Yun-Seok Rhee, Xiao Wu
1University of Kentucky, College of Pharmacy, Division of Pharmaceutical Sciences-Drug Development Division, Lexington, KY 40536, USA. heidi.mansour@uky.edu
International Journal of Nanomedicine
|January 8, 2010
Summary
Colloidal carriers, or nanocarrier systems, enhance pulmonary drug delivery by improving drug distribution, solubility, and sustained release for respiratory diseases. This review explores their pharmaceutical aspects, manufacturing, and evaluation for lung applications.
Area of Science:
- Pharmacology
- Nanotechnology
- Respiratory Medicine
Background:
- The lung offers advantages for drug delivery, including noninvasive administration and direct action for respiratory diseases.
- Colloidal carriers (nanocarrier systems) can optimize drug distribution, solubility, and release in the lungs.
Purpose of the Study:
- To review the current status and potential of colloidal carriers in pulmonary drug delivery.
- To focus on pharmaceutical aspects, manufacturing, evaluation, and regulatory considerations.
Main Methods:
- Literature review of nanocarrier systems for pulmonary drug delivery.
- Discussion of pharmaceutical considerations, manufacturing processes, and in vitro/in vivo evaluation.
Main Results:
- Colloidal carriers offer uniform drug distribution, improved solubility, and sustained release.
- They can enhance drug internalization by cells, reduce dosing frequency, and improve patient compliance.
Conclusions:
- Nanocarrier systems show significant potential for advanced pulmonary drug delivery.
- Further research into manufacturing, evaluation, and regulatory aspects is crucial for clinical translation.
Related Concept Videos
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
01:23Inhaled Medications
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
01:16Drug Delivery: Overview
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...