Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physicochemical Stability and Cross-Context Validation of PEGylated Human Serum Albumin Nanoparticles for Dual Neurotrophin Delivery in the Rabbit Eye and Oxidative Stress Models.

International journal of nanomedicine·2026
Same author

Alteplase before mechanical thrombectomy: which patients benefit from this bridging therapy?

Neurologia i neurochirurgia polska·2026
Same author

Fibroblast-Based Cell Therapy: Molecular Background, Current Therapies and Future Perspectives.

Cells·2026
Same author

Neurotrophins Plasma Levels Kinetics in Ischemic Stroke Patients-Potential Relation to Outcomes.

Neurology international·2026
Same author

Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery.

Scientific reports·2026
Same author

Development of a prognostic scoring system for chronic myeloid leukemia in blast phase.

Leukemia·2026

Related Experiment Video

Updated: Jun 17, 2026

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
09:24

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

[Stem cell-based therapy in central nervous system diseases].

Edyta Paczkowska1, Elzbieta Dabkowska, Przemysław Nowacki

  • 1Zakład Patologii Ogólnej, Pomorska Akademia Medyczna, ul. Powstańców Wlkp. 71, 70-111 Szczecin.

Neurologia I Neurochirurgia Polska
|January 8, 2010
PubMed
Summary

Very small embryonic-like stem cells (VSEL SCs) offer hope for regenerative medicine. These cells, found in bone marrow and cord blood, present an ethically sound alternative to embryonic stem cells for tissue repair.

More Related Videos

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Related Experiment Videos

Last Updated: Jun 17, 2026

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
09:24

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Neurodegenerative disorders

Context:

  • Current stem cell research focuses on tissue and organ regeneration.
  • Autologous bone marrow stem cells are a potential therapeutic alternative.
  • Nervous tissue regeneration in CNS disorders presents a significant challenge.

Purpose:

  • To explore the potential of very small embryonic-like stem cells (VSEL SCs) for regenerative medicine.
  • To evaluate VSEL SCs as an alternative to embryonic stem cells.

Summary:

  • Very small embryonic-like stem cells (VSEL SCs) have been identified in murine bone marrow and human umbilical cord blood.
  • VSEL SCs exhibit characteristics of embryonic stem cells, including pluripotent markers (Oct-4, Nanog, SSEA-4).
  • These cells offer potential advantages over embryonic stem cells due to ethical considerations.

Impact:

  • VSEL SCs may provide a viable cell source for regenerative therapies.
  • This research could lead to novel treatments for neurodegenerative diseases.
  • Ethical concerns associated with embryonic stem cells may be circumvented.