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Updated: Apr 14, 2026

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
Published on: April 3, 2021
Fibroblast-Based Cell Therapy: Molecular Background, Current Therapies and Future Perspectives
Paulina Bihuniak1, Patrycja Stodolak1,2, Piotr Kulig1,2
1Pharmaceutical Facility of Pomeranian Medical University, Pomeranian Medical University, 70-252 Szczecin, Poland.
Abstract:
Fibroblasts are mesenchymal cells which physiologically possess numerous functions and belong to basic cellular components necessary to maintain tissue homeostasis and are essential for extracellular matrix formation and maintenance. In addition, fibroblasts are of paramount importance in regeneration and wound healing as they interact with the immune system. These unique properties determine their great utility in cell therapies in the field of regenerative medicine. This review summarizes the mechanisms of action and clinical applications of fibroblast-based therapies as well as highlighting the future perspectives including the use of allogeneic cells.
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