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Updated: Jun 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents
Sumesh Eswaran1, Airody Vasudeva Adhikari, Nishith K Pal
1Anthem Biosciences Pvt Ltd, 49 Bommasandra Industrial Area, Bommasandra, Bangalore 560 099, Karnataka, India.
Abstract:
A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC(2)), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.
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