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Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

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Published on: January 10, 2025

[Laboratory work-up of testosterone].

M Trottmann¹, M Dickmann, C G Stief

¹Urologische Klinik und Poliklinik, Klinikum der Universität München - Grosshadern, München. matthias.trottmann@med.uni-muenchen.de

Der Urologe. Ausg. A

|January 9, 2010

Summary

Accurate testosterone measurement is key in andrology. Factors like age, circadian rhythm, and medications influence levels, requiring careful interpretation, especially in elderly patients lacking standard values.

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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

Area of Science:

Andrology
Endocrinology
Clinical Diagnostics

Context:

Testosterone level measurement is crucial for andrological diagnostics.
Direct bioavailable testosterone measurement can be complex and imprecise.
Calculation using sex hormone-binding globulin (SHBG) and albumin concentrations offers an alternative.

Purpose:

To highlight the importance of considering various influencing factors when interpreting testosterone concentrations.
To emphasize the challenges in diagnosing testosterone deficiency, particularly in the elderly.
To underscore the need for individualized assessment in hormone substitution decisions.

Summary:

Interpreting testosterone levels requires accounting for circadian rhythm, age-related decline, illness, and drug intake.
Sex hormone-binding globulin (SHBG) concentration increases with age, impacting testosterone bioavailability.
Lack of standardized values for elderly patients necessitates symptom-based evaluation for hormone therapy.

Impact:

Provides a comprehensive overview of factors affecting testosterone levels for clinicians.
Improves the accuracy of testosterone level interpretation in routine andrological practice.
Guides clinical decision-making regarding testosterone hormone substitution, especially in aging populations.