Related Experiment Video
Updated: Jul 28, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Anaplastic large cell Ki-1 lymphoma arising in bone
M S Edwards1, J Fairbank, P Midgely
1Nuffield Orthopaedic Centre, Oxford, UK.
Summary
Anaplastic large cell Ki-1 lymphoma is a rare cancer. This case report details the diagnosis and treatment of this rare tumor in a 14-year-old boy with thoracic vertebrae involvement.
Area of Science:
- Oncology
- Hematology
- Pediatric Oncology
Background:
- Anaplastic large cell Ki-1 lymphoma (ALCL) is a rare non-Hodgkin lymphoma.
- ALCL predominantly affects lymph nodes, skin, and the gastrointestinal tract.
- Primary bone involvement is exceptionally rare in ALCL.
Observation:
- A 14-year-old boy presented with symptoms suggestive of spinal cord compression.
- Diagnostic imaging revealed involvement of two thoracic vertebrae.
- Biopsy confirmed the presence of anaplastic large cell Ki-1 lymphoma.
Findings:
- The patient was diagnosed with primary anaplastic large cell Ki-1 lymphoma of the thoracic vertebrae.
- Treatment involved a multidisciplinary approach including chemotherapy and radiation therapy.
- Successful management and remission were achieved.
Implications:
- This case highlights the importance of considering rare presentations of ALCL in pediatric patients.
- It underscores the need for prompt diagnosis and tailored treatment strategies for primary bone lymphomas.
- Further research into the pathogenesis and optimal management of extranodal ALCL is warranted.
