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Updated: Jun 17, 2026

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
Published on: June 16, 2020
[Cardiac conduction disorders in the elderly]
Jean-Marc Davy1, Frédéric Cransac, François Roubille
1Département de cardiologie, CHU de Montpellier, hôpital Arnaud-de-Villeneuve, Montpellier, France. jm-davy@chu-montpellier.fr
Insights
Heart conduction disorders, common in aging, often require pacing. Clinical syncope evaluation is crucial for diagnosis and treatment decisions, especially in the elderly.
Area of Science:
- Cardiology
- Electrophysiology
- Geriatrics
Context:
- Conduction disorders (sinus node, AV node, His bundle) are common in aging hearts.
- Elderly patients frequently use medications (beta-blockers, calcium-blockers, digoxin) that can exacerbate conduction issues.
- Diagnosing syncope in the elderly is challenging, often requiring clinical assessment over diagnostic tests.
Purpose:
- To review the causes and management of cardiac conduction disorders in the elderly.
- To emphasize the importance of clinical evaluation in diagnosing syncope.
- To outline indications for permanent pacemaker implantation.
Summary:
- Left bundle branch block suggests cardiac disease, while multi-level conduction disorders are typical of aging.
- Sinus node and AV nodal blocks are common in the elderly and can be worsened by essential medications.
- Accurate diagnosis of syncope relies on clinical presentation, as electrophysiological studies can be inconclusive.
Impact:
- Highlights the diagnostic challenges and therapeutic considerations for conduction disorders and syncope in the elderly population.
- Underscores the critical role of clinical judgment in pacemaker implantation decisions.
- Suggests further research into the links between sinus dysfunction, carotid sinus syndrome, and sleep apnea.
Abstract:
While the left bundle branch block frequently reflects underlying cardiac disease, conductive disorders occurring at three levels (sinus node, atrioventricular node, and branches of the bundle of His), are usually part of the aging heart. In addition, AV nodal block and sinus node dysfunction are readily compounded with drugs, often indispensable (beta-blockers, calcium-blockers, digoxin, antiarrhythmic), and very common among the elderly. Indications for permanent pacing are accurately described and come in four classes: I, recommended (mandatory) - IIa, raisonable - IIb, possible - III, contraindicated. In 2009, 24H ECG Holter and electrophysiological study are generally disappointing in the positive diagnosis of syncope, so the clinical characteristics of syncope are essential in the decision of device implantation. Indeed, in the absence of ECG recorded at the time of the syncope, the diagnosis of BAV or BSA cannot be certain, and on the contrary, vague symptoms should not be attributed to a patent bradycardia of sinus or AV block origin without any precaution. Finally, the relationship between sinus dysfunction and carotid sinus syndrome remain poorly understood, dysautonomia is common among the elderly, and the existence of conduction disorders associated with syndrome of sleep apnea should not be ignored.
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