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Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

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General functionalization route for cell adhesion on non-wetting surfaces.

Sook Hee Ku1, Jungki Ryu, Seon Ki Hong

  • 1Department of Materials Science and Engineering, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.

Biomaterials
|January 12, 2010
PubMed
Summary

Researchers developed a mussel-inspired method using poly(dopamine) coatings to enhance cell adhesion on non-wetting surfaces. This versatile, non-toxic technique transforms bioinert materials into bioactive substrates for improved cell viability.

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Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cell Biology

Background:

  • Non-wetting surfaces often exhibit poor cell adhesion, limiting their biomedical applications.
  • Mussel adhesive proteins provide a natural model for robust surface interactions.
  • Developing methods to improve cell adhesion on bioinert materials is crucial for tissue engineering and regenerative medicine.

Purpose of the Study:

  • To present a versatile and efficient method for promoting cell adhesion and viability on non-wetting surfaces.
  • To investigate the potential of dopamine polymerization for surface functionalization.
  • To demonstrate the efficacy of poly(dopamine) coatings on various substrates, including anti-adhesive materials.

Main Methods:

  • Utilized the oxidative polymerization of dopamine to create a poly(dopamine) ad-layer on diverse material surfaces.
  • Applied poly(dopamine) coatings to non-wetting substrates, including poly(tetrafluoroethylene).
  • Assessed mammalian cell adhesion, spreading, and cytoskeleton development on modified and unmodified surfaces.

Main Results:

  • Poly(dopamine) coatings successfully promoted significant cell adhesion and spreading on all tested non-wetting surfaces.
  • Mammalian cells exhibited robust attachment, spreading, and cytoskeleton development on poly(dopamine)-modified substrates.
  • Unmodified non-wetting surfaces showed minimal cell adhesion and spreading.

Conclusions:

  • Mussel-inspired poly(dopamine) surface functionalization is a highly effective strategy for enhancing cell adhesion and viability.
  • This solvent-free, non-toxic method offers a powerful route to convert bioinert materials into bioactive surfaces.
  • The technique eliminates the need for complex linker synthesis, providing a versatile approach for biomaterial development.