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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Endocrine aspects of obstructive sleep apnea
Pierre Attal1, Philippe Chanson
1Service d'Endocrinologie et des Maladies de la Reproduction, Hôpital de Bicêtre, F-94275 Le Kremlin-Bicêtre, France.
The Journal of Clinical Endocrinology and Metabolism
|January 12, 2010
Summary
Endocrine disorders like hypothyroidism can cause obstructive sleep apnea (OSA), and treating them may cure it. If OSA persists, continuous positive airway pressure therapy is recommended.
Area of Science:
- Endocrinology
- Sleep Medicine
- Cardiovascular Medicine
Background:
- Obstructive sleep apnea (OSA) is frequently associated with endocrine and metabolic disorders.
- Treatment of underlying endocrine conditions can improve or resolve OSA.
- OSA is linked to increased cardiovascular risk and potential glucose metabolism disturbances.
Purpose of the Study:
- To review the association between endocrine/metabolic disorders and OSA.
- To examine the pathophysiological mechanisms linking these conditions.
- To discuss treatment implications and recommendations.
Main Methods:
- A review of the medical literature was conducted.
- Key articles published up to June 2009 were included.
Main Results:
- Endocrine conditions such as obesity, acromegaly, hypothyroidism, and polycystic ovary disease are linked to OSA.
- OSA may be resolved by treating hypothyroidism and acromegaly, due to reversible pharyngeal wall thickening.
- OSA can persist despite endocrine treatment if irreversible factors like skeletal defects or obesity are present.
Conclusions:
- Specific OSA therapy, such as continuous positive airway pressure (CPAP), is advised if OSA remains after treating underlying endocrine/metabolic causes.
- Untreated OSA carries risks including neurocognitive impairment and increased cardiovascular disease.
- Effective management of OSA is crucial, especially when associated with endocrine and metabolic conditions.
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