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Updated: Jun 17, 2026

Live-imaging of the Drosophila Pupal Eye
Published on: January 12, 2015
Drosophila Kelch functions with Cullin-3 to organize the ring canal actin cytoskeleton
1Department of Genetics, Yale University, New Haven, CT 06520, USA.
Abstract:
Drosophila melanogaster Kelch (KEL) is the founding member of a diverse protein family defined by a repeated sequence motif known as the KEL repeat (KREP). Several KREP proteins, including Drosophila KEL, bind filamentous actin (F-actin) and contribute to its organization. Recently, a subset of KREP proteins has been shown to function as substrate adaptor proteins for cullin-RING (really interesting new gene) ubiquitin E3 ligases. In this study, we demonstrate that association of Drosophila KEL with Cullin-3, likely in a cullin-RING ligase, is essential for the growth of Drosophila female germline ring canals. These results suggest a role for protein ubiquitylation in the remodeling of a complex F-actin cytoskeletal structure.
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