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High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
Opsoclonus-myoclonus syndrome in anti-N-methyl-D-aspartate receptor encephalitis
Mary Kurian1, Patrice H Lalive, Josep O Dalmau
1Department of Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Background:
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis has been recently reported as autoimmune/paraneoplastic encephalitis, affecting mostly young females.
Objective:
To describe opsoclonus-myoclonus syndrome in association with anti-NMDAR antibodies.
Design:
Case report.
Setting:
Geneva University Hospital. Patient A 23-year-old woman with opsoclonus-myoclonus syndrome.
Results:
Two weeks after an episode of gastroenteritis, the patient developed symptoms of depression associated with psychomotor slowing, progressive gait instability, and opsoclonus-myoclonus. Cerebrospinal fluid examination showed mild lymphocytic pleocytosis and intrathecal IgG synthesis with oligoclonal bands. The patient's condition worsened rapidly to an akinetic mutism, followed by a period of agitation, delirium, and hallucinations. These gradually subsided; however, a frontal behavior and executive dysfunction persisted 5 months after symptom presentation. No tumor was found. Anti-NMDAR antibodies were found in the cerebrospinal fluid.
Conclusions:
Opsoclonus-myoclonus may occur in patients with anti-NMDAR encephalitis. Prompt diagnosis of this disorder is important because after tumor removal and immunomodulatory therapies it has a relatively good prognosis.
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