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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

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Published on: March 23, 2022

Epithelium: the interplay between innate and Th2 immunity.

Katarzyna Bulek¹, Shadi Swaidani, Mark Aronica

¹Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA.

Immunology and Cell Biology

|January 13, 2010

Summary

The mucosal epithelium regulates immune responses through epithelial-derived cytokines like IL-25 and IL-33, crucial for maintaining immune homeostasis and defense against pathogens.

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Area of Science:

Immunology
Cell Biology
Epithelial Biology

Background:

The mucosal epithelium acts as a physical barrier and immune regulator.
Epithelial cells are key in initiating T-helper 2 (Th2) immune responses.
These cells bridge innate immunity and adaptive Th2 immunity.

Purpose of the Study:

To elucidate the mechanisms of epithelial modulation of Th2 responses.
To highlight the role of epithelial-derived cytokines in mucosal immunity.
To understand the implications of dysregulated Th2 responses in inflammatory diseases.

Main Methods:

Analysis of cellular and molecular mechanisms.
Investigation of cytokine production by epithelial cells.
Review of emerging studies on epithelial-derived cytokines.

Main Results:

Epithelial cells produce key Th2-driving cytokines: interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin.
These cytokines promote Th2 responses, maintaining immune homeostasis.
Dysregulation is linked to Th2-dependent inflammatory and allergic diseases.

Conclusions:

The epithelium critically regulates mucosal immunity via specific cytokines.
Maintaining the balance of these cytokines is vital for host defense.
Aberrant cytokine signaling contributes to allergic and inflammatory conditions.