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Updated: Jun 17, 2026

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Published on: July 8, 2021
Role of the transcription factor NFIC in odontoblast gene expression
Mi Young Kim1, Julia Reyna, Li-Sha Chen
1University of Southern California, School of Dentistry, Los Angeles, USA.
Abstract:
The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.
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