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Updated: Jun 17, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Neuropsychiatric manifestations in systemic sclerosis]
David Launay1, Thierry Baubet, Olivier Cottencin
1Université Lille 2, Service de médecine interne, Centre de référence de la sclérodermie systémique, Hôpital Claude-Huriez, CHRU Lille, F-59037 Lille Cedex, France.
Presse Medicale (Paris, France : 1983)
|January 14, 2010
Summary
Systemic sclerosis (SSc) can affect the central nervous system (CNS), contrary to previous beliefs. Studies reveal higher rates of depression, cognitive issues, and brain abnormalities like leukoaraiosis in SSc patients, suggesting a potential for "neuropsychiatric scleroderma".
Area of Science:
- Neurology
- Rheumatology
- Neuroscience
Context:
- Systemic sclerosis (SSc) was historically considered to not affect the central nervous system (CNS).
- Neurological symptoms are rare, but neuropsychiatric manifestations like depression and cognitive impairment are increasingly recognized in SSc.
- Brain imaging studies reveal higher incidences of calcifications and leukoaraiosis in SSc patients compared to controls.
Purpose:
- To investigate the prevalence and characteristics of central nervous system involvement in systemic sclerosis.
- To explore the association between central nervous system abnormalities and neuropsychiatric symptoms in SSc patients.
- To determine if CNS findings could define a distinct clinical entity of
Summary:
- Systemic sclerosis (SSc) can involve the central nervous system (CNS), manifesting as higher rates of depression (17-65%) and cognitive impairment.
- Brain imaging reveals increased brain calcifications and leukoaraiosis (white matter lesions) in SSc patients.
- Severe leukoaraiosis correlates with vascular issues, suggesting a link between CNS morphology and neuropsychiatric symptoms.
Impact:
- This research could lead to the identification of
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