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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Amisulpride improved debilitating clozapine-induced sialorrhea
Samir Kumar Praharaj1, Prasenjit Ray, Sachin Gandotra
1Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India. samirpsyche@yahoo.co.in
American Journal of Therapeutics
|January 14, 2010
Summary
Amisulpride effectively reduced clozapine-induced sialorrhea, a common side effect impacting treatment adherence. This case study highlights its potential for managing excessive salivation, particularly during the day.
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Medicine
Background:
- Clozapine is an essential antipsychotic medication.
- Clozapine-induced sialorrhea is a frequent and distressing adverse effect.
- Poor treatment compliance is often linked to clozapine-induced sialorrhea.
Observation:
- This case study investigated the efficacy of amisulpride in managing clozapine-induced sialorrhea.
- The study focused on a patient experiencing troublesome daytime and nocturnal sialorrhea.
Findings:
- Amisulpride, at a dosage of 150 mg/day, significantly alleviated daytime sialorrhea.
- Minimal improvement was observed in nocturnal sialorrhea with amisulpride treatment.
Implications:
- Amisulpride presents a potential therapeutic option for managing clozapine-induced sialorrhea.
- Further research is warranted to confirm efficacy and optimal dosing for both daytime and nocturnal symptoms.
- Effective management of sialorrhea may improve patient compliance with clozapine therapy.
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