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Cutaneous cellulitis.

M K Sachs1

  • 1Division of Infectious Diseases, Jefferson Medical College, Philadelphia, Pa 19107.

Archives of Dermatology
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

Cellulitis infection involves bacterial invasion and the skin's immune response. Intra-epidermal immunocompetent cells and anti-inflammatory agents may help resolve bacterial skin infections.

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Area of Science:

  • Dermatology
  • Immunology
  • Microbiology

Background:

  • Cellulitis is commonly believed to stem from bacterial invasion and proliferation.
  • Difficulty in isolating pathogens from affected skin challenges this traditional hypothesis.
  • The skin possesses specialized immune cells capable of secreting cytokines and lymphokines.

Purpose of the Study:

  • To investigate the role of the skin's immune microenvironment in cellulitis pathogenesis.
  • To explore the contribution of lymphokines and cytokines to cellulitis symptoms.
  • To assess the potential impact of anti-inflammatory agents on cellulitis resolution.

Main Methods:

  • Review of existing literature on cellulitis and skin immunology.
  • Analysis of the proposed mechanisms of bacterial clearance by skin immune cells.

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  • Examination of the inflammatory mediators involved in cellulitis.

    • Main Results:

    • Skin immune cells (lymphoid and reticular) secrete lymphokines and cytokines.
    • These mediators enhance macrophage and neutrophil infiltration, reducing bacterial load.
    • Bacterial remnants and amplified lymphokines likely cause cellulitis's characteristic warmth and erythema.

    Conclusions:

    • Cellulitis pathogenesis involves both bacterial presence and a complex immune response.
    • Intra-epidermal immunocompetent cells play a crucial role in managing bacterial skin infections.
    • Anti-inflammatory agents may aid in cellulitis treatment by modulating immune mediator production.