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Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
Published on: March 29, 2020
[Arterial thromboembolism in cats].
M J M Dirven1, J M M Cornelissen
1Dierenkliniek Rijen, kliniek voor gezelschapsdieren, Rijen, Nederland. mark_dirven@hotmail.com
Tijdschrift Voor Diergeneeskunde
|January 15, 2010
Summary
Arterial thromboembolism is a rare but severe feline disease, often linked to cardiomyopathy. Current treatments offer limited impact on outcomes, highlighting the need for better prevention and management strategies.
Area of Science:
- Veterinary Medicine
- Cardiology
- Thrombosis
Context:
- Arterial thromboembolism (ATE) is a critical condition in cats, with a prevalence under 0.57%.
- Cardiomyopathy is the most frequent underlying cause of ATE in felines.
- Clinical signs include severe pain, hind limb paralysis, and absent distal pulses.
Purpose:
- This review synthesizes current knowledge on feline arterial thromboembolism.
- It details the pathophysiology, clinical presentation, diagnostic approaches, and therapeutic interventions for ATE.
- The review also addresses risk factors and emerging strategies for prevention and treatment.
Summary:
- ATE in cats typically involves thrombi lodging at the aortic trifurcation, leading to acute limb ischemia.
- Management focuses on palliative care, thrombolysis, and preventing recurrent clot formation.
- Prognosis remains guarded, with medical interventions showing limited influence on the overall outcome.
Impact:
- This review provides a comprehensive resource for veterinarians managing feline ATE.
- It emphasizes the importance of understanding underlying causes like cardiomyopathy.
- The summary of new developments aims to improve clinical outcomes and prevention strategies for this devastating condition.
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