Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing.

Development (Cambridge, England)·2026
Same author

Confined migration induces non-lethal DNA damage in developing neurons.

Nature·2026
Same author

Right Bundle Branch Conduction in Left Bundle Branch Area Pacing.

Journal of arrhythmia·2026
Same author

Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same author

Pri micropeptide functions as a cell-intrinsic timer controlling the transient phase of cell fate induction.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Development and Field Validation of a Smartphone-Based Web Application for Diagnosing Optimal Timing of Mid-Season Drainage in Rice Cultivation via Canopy Image-Derived Tiller Estimation.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 17, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Computational modeling of dendritic tiling by diffusible extracellular suppressor.

Kohei Shimono1, Kaoru Sugimura, Mineko Kengaku

  • 1Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
|January 15, 2010
PubMed
Summary

This study models how neuronal dendrites form tiling patterns, essential for brain function. Mathematical models show that interactions with extracellular suppressors guide dendrite growth and regeneration, ensuring proper neural network formation.

More Related Videos

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Related Experiment Videos

Last Updated: Jun 17, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Area of Science:

  • Neuroscience
  • Computational Biology
  • Developmental Biology

Background:

  • Neuronal class-specific dendrites are crucial for nervous system function.
  • Dendritic arbor tiling ensures uniform input stimulus reception.
  • Previous research suggested contact-dependent retraction or extracellular suppressors mediate dendritic tiling.

Purpose of the Study:

  • To mathematically model the development and regeneration of dendritic tiling patterns.
  • To investigate the role of extracellular suppressors in dendritic arbor formation.
  • To explore mechanisms underlying both non-overlapping and overlapping dendritic arbors.

Main Methods:

  • Development of two mathematical models: the cell compartment model and the end capped-segment model.
  • Coupling dendrite growth dynamics with extracellular suppressor dynamics.
  • Analysis of the end capped-segment model in 3D space to simulate arbor patterns.

Main Results:

  • Both models successfully reproduced dendritic tiling patterns.
  • The end capped-segment model generated both non-overlapping and overlapping dendritic arbors.
  • Numerical analysis suggested tiling can be achieved by modulating intracellular activators or extracellular suppressor production.

Conclusions:

  • Dendritic tiling patterns can be explained by models incorporating extracellular suppressor dynamics.
  • The models provide insights into mechanisms underlying normal tiling and tiling mutant phenotypes.
  • Modulation of local suppressor or activator concentrations may be key to achieving specific dendritic arbor patterns.