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Published on: May 26, 2023
Metal-organic frameworks as potential drug carriers
Rachel C Huxford1, Joseph Della Rocca, Wenbin Lin
1Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, NC 27599, USA.
Nanoscale metal-organic frameworks (NMOFs) show promise for drug delivery due to high drug loading and biodegradability. Further improvements are needed for NMOFs to become effective nanotherapeutics in clinical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmacology
Background:
- Nanoparticle-based therapeutics offer advantages over conventional treatments.
- Metal-organic frameworks (MOFs) are hybrid materials suitable for drug delivery.
- Nanoscale MOFs (NMOFs) are being explored as advanced drug delivery vehicles.
Purpose of the Study:
- To review the potential of NMOFs in drug delivery applications.
- To highlight the advantages of NMOFs, including high drug loading and biodegradability.
- To identify areas for improvement in NMOF development for therapeutic use.
Main Methods:
- Literature review of MOF and NMOF applications in drug delivery.
- Analysis of NMOF properties relevant to therapeutic use, such as drug loading capacity and release profiles.
- Examination of specific examples, including cisplatin prodrug delivery.
Main Results:
- MOFs can encapsulate and release various therapeutics.
- NMOFs demonstrate potential for selective drug delivery.
- NMOFs offer high drug loadings and tunable functionalities.
Conclusions:
- NMOFs represent a promising platform for advanced drug delivery systems.
- Further research and development are essential to overcome current limitations.
- NMOFs require optimization to become viable nanotherapeutics.
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