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Updated: Jun 17, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Executive summary of the workshop on infection in the high-risk infant
R D Higgins1, C J Baker, T N K Raju
1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. higginsr@mail.nih.gov
Insights
Neonatal infections pose a significant threat to infants in intensive care. Further research is crucial for improved diagnosis, treatment, and prevention strategies to reduce infant morbidity and mortality.
Area of Science:
- Neonatal research
- Infectious disease in newborns
- Intensive care medicine
Background:
- Neonatal infections remain a primary cause of morbidity and mortality in intensive care units (ICUs).
- Infants face risks from early-onset, late-onset, and hospital-acquired infections.
- Current neonatal care advances have not fully mitigated the burden of infections.
Framework:
- A workshop convened by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in August 2008 addressed critical knowledge gaps.
- The workshop focused on identifying barriers to optimal, evidence-based care for perinatal and neonatal infections.
- Discussions aimed to prioritize research directions in this vital area.
Implementation:
- The paper summarizes key discussions from the NICHD workshop.
- It highlights major knowledge gaps in understanding and managing neonatal infections.
- Prioritized research suggestions are presented to guide future studies.
Implications:
- Addressing identified knowledge gaps is essential for advancing neonatal infection control.
- Optimizing timely diagnosis and treatment protocols is a key recommendation.
- Developing patient-specific and system-wide prevention strategies is critical for reducing infection rates.
Abstract:
For newborn infants in intensive care units, the morbidity and mortality from infection continues to be a major burden despite advances in neonatal care. Infants are at risk for early-onset, late-onset as well as hospital-acquired infections. Research studies are needed to optimize timely diagnosis and treatment, and develop patient-specific and system-wide strategies to prevent perinatal and neonatal infections. To address the knowledge gaps that preclude optimal, evidence-based care in this critical field, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) organized a workshop in August 2008. In this paper, we provide a summary of the discussions, focusing on major knowledge gaps, and prioritized suggestions for research in this area.
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