Oxidative stress and obstructive sleep apnoea syndrome
T D Singh1, K Patial, V K Vijayan
1Department of Physiology, V P Chest Institute, University of Delhi, Delhi, India.
The Indian Journal of Chest Diseases & Allied Sciences
|January 16, 2010
Summary
Antioxidant treatment, including vitamins C and E, improved sleep quality and reduced oxidative stress in patients with obstructive sleep apnoea syndrome (OSAS). This suggests oxidative stress plays a role in OSAS symptoms.
Area of Science:
- Sleep Medicine
- Oxidative Stress Research
- Nutritional Supplementation
Background:
- Oxidative stress is implicated in obstructive sleep apnoea syndrome (OSAS) symptoms.
- Limited data exists on antioxidant treatment efficacy for OSAS symptom improvement.
Purpose of the Study:
- To evaluate the impact of antioxidant therapy on polysomnographic (PSG) parameters.
- To assess changes in oxidative stress markers in OSAS patients receiving antioxidants.
Main Methods:
- 20 male OSAS patients underwent PSG, followed by CPAP therapy and oral Vitamin C/E supplementation for 45 days, with repeat PSG.
- A control group of 10 healthy subjects followed the same protocol excluding CPAP.
Main Results:
- OSAS patients showed elevated lipid peroxidation and reduced glutathione, which normalized with CPAP and antioxidant treatment.
- Antioxidant intake improved sleep quality, decreasing Epworth sleepiness scores and apnoeic episodes.
- Patients experienced increased time in deep sleep stages (3 and 4), and optimal CPAP pressure was reduced.
Conclusions:
- Oxidative stress is a contributing factor to sleep disturbances in OSAS.
- Antioxidant supplementation enhances sleep quality in individuals with OSAS.
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