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Updated: Jun 17, 2026

Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications
Published on: April 21, 2023
Ubiquitin and SUMO signalling in DNA repair
Timothy M Thomson1, Marta Guerra-Rebollo
1Laboratory of Cell Signaling and Cancer, Department of Cell Biology, Instituto de Biología Molecular de Barcelona, Consejo Superior de Investigaciones Científicas, Parque Científico de Barcelona, Edificio Hélice, Baldiri Reixac 15-21, 08028 Barcelona, Spain. titbmc@ibmb.csic.es
Abstract:
The repair of lesions and gaps in DNA follows different pathways, each mediated by specific proteins and complexes. Post-translational modifications in many of these proteins govern their activities and interactions, ultimately determining whether a particular pathway is followed. Prominent among these modifications are the addition of phosphate or ubiquitin (and ubiquitin-like) moieties that confer new binding surfaces and conformational states on the modified proteins. The present review summarizes some of consequences of ubiquitin and ubiquitin-like modifications and interactions that regulate nucleotide excision repair, translesion synthesis, double-strand break repair and interstrand cross-link repair, with the discussion of relevant examples in each pathway.
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