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Updated: Jan 20, 2026
Endocytosis and Exocytosis; Clathrin Coated Pits and SNAREs
Published on: April 29, 2023
The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?
Irit Gottfried1, Marcelo Ehrlich, Uri Ashery
1Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Abstract:
HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p. All three members of the family have a conserved domain structure, suggesting a common function. Over the past decade, a number of studies have characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins, though some differences have emerged. In this mini-review we summarize the current views on the roles of these proteins, while emphasizing the unique attributes of each family member.
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