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Related Experiment Video

Updated: Jun 17, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

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Autonomic dysfunction and neuropeptide Y in fibromyalgia.

M Di Franco¹, C Iannuccelli, C Alessandri

¹Unit of Rheumatology, Sapienza University of Rome, Rome, Italy. manuela.difranco@uniroma1.it

Clinical and Experimental Rheumatology

|January 16, 2010

Summary

Fibromyalgia patients exhibit autonomic nervous system dysfunction and elevated neuropeptide Y (NPY) levels, suggesting their role in the condition. Further research is needed to understand NPY and ANS in pain and immunity.

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Published on: June 25, 2019

Area of Science:

Neuroscience
Immunology
Rheumatology

Background:

Fibromyalgia (FM) presents with widespread pain and multisystem symptoms.
Autonomic nervous system (ANS) dysfunction may explain several FM features.

Purpose of the Study:

To investigate ANS dysfunction in FM patients.
To analyze serum neuropeptide Y (NPY) levels and heart rate variability (HRV).

Main Methods:

Compared 51 FM patients, 25 systemic sclerosis (SSc) patients, and 15 healthy controls (NHS).
Utilized time-domain HRV analysis and measured serum NPY levels.

Main Results:

FM patients showed significantly higher NPY levels than SSc and NHS groups.
A subgroup of FM patients (49%) had reduced HRV indices.
NPY levels correlated with specific HRV indices (SDANN, NN50) in the FM subgroup.

Conclusions:

Autonomic dysfunction and NPY are implicated in fibromyalgia pathophysiology.
Further studies are required to elucidate the roles of NPY and ANS in pain and immune modulation.