Related Experiment Video
Updated: Jun 17, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
Glucose-responsive composite microparticles based on chitosan, concanavalin A and dextran for insulin delivery
Ruixue Yin1, Jing Han, Jianfeng Zhang
1State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Abstract:
Glucose-responsive systems are very useful for self-regulated insulin delivery. In this study, glucose-responsive composite microparticles based on chitosan, concanavalin A and dextran were prepared by first fabricating chitosan microparticles subsequently coupling concanavalin A via Schiff-base reaction and dextran layer via specific affinity. SEM, fluorescence microscope, XPS and TGA were used to characterize the morphology and composition of the microparticles. SEM results indicated that the microparticles could exist individually and in a spherelike shape. The fluorescence image showed that the microparticles were well dispersed with an average diameter of 2.5 microm. The XPS and TGA data confirmed the composite layers of the microparticles. Insulin could be loaded into the microparticles due to electrostatic and intermolecular interaction with high entrapment efficiency of 92.2% and loading capacity of 9.1%. The release profiles of insulin revealed that the insulin release was in response to the glucose concentration in the medium and the glucose sensitivity was reversible. The released insulin was proved to remain active through the whole process. The results suggest that this composite microparticle may be a promising system for self-regulated insulin delivery.
More Related Videos
09:31Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
09:39Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Related Concept Videos
Insulin Secretory Vesicles
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into rapid-acting...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Oral Hypoglycemic Agents: Glinides
Production of Pharmaceuticals