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Updated: Jun 17, 2026

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
[Natural orifice transluminal endoscopic surgery: current situation].
Paulo Vicente dos Santos Filho1, Marcelo Protásio dos Santos, João Eduardo Marques Tavares de Menezes Ettinger
1Escola Bahiana de Medicina e Saúde Pública, Salvador - Bahia. paulovicentefilho@gmail.com
Natural orifice transluminal endoscopic surgery (NOTES) offers a novel approach to abdominal procedures, bypassing incisions. While feasible in animal models, further research is crucial to ensure human safety and efficacy.
Area of Science:
- Minimally Invasive Surgery
- Gastroenterology
- Surgical Innovation
Context:
- Natural orifice transluminal endoscopic surgery (NOTES) emerged in 2004 as an experimental surgical alternative.
- It combines endoscopic and laparoscopic techniques to access abdominal organs via natural orifices.
- This approach aims to eliminate abdominal incisions and associated complications.
Purpose:
- To explore the potential of NOTES as a less invasive surgical option.
- To review the current status and limitations of transluminal surgery.
- To provide recommendations for advancing NOTES toward human clinical trials.
Summary:
- NOTES accesses the abdominal cavity through a natural orifice under endoscopic visualization.
- Preliminary studies in animal models show the technique's feasibility.
- Significant research is still needed to establish its safety and effectiveness in humans.
Impact:
- Potential to revolutionize abdominal surgery by eliminating external incisions.
- Could reduce patient recovery times and surgical site infections.
- Highlights the need for rigorous validation before widespread human application.
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