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Updated: Jun 17, 2026
Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
Published on: September 2, 2025
[Ultrasound guided core biopsy for breast lesions using 16G needle]
Elizabeth Costa Martins1, Alkindar Soares, Carlos Marques Guimarães
1Pós-Graduação em Ginecologia da Santa Casa da Misericórdia do Rio de Janeiro, RJ, BR. elizabeth.martins@uol.com.br
Objective:
The objective of this study was to develop a standard diagnostic evaluation with 16G core-needle biopsy for breast lesions. We evaluated the ideal number of fragments using standard ultrasound criteria based on the previous results obtained on the size of the lesions.
Methods:
A prospective study was carried out, from may 2004 to September 2005, in 79 patients with lesions that included categories 2,3,4 and 5, according to BIRADS -USTM using 16G core biopsy needle. We took up 5 pieces numbered and placed individually in vials with 10% formalin.
Results:
In 84 biopsies performed there were 81 conclusive diagnoses (96%), with 43 malignant results (51%) and 38 benign results (45%). The effectiveness of the core biopsy increased with the sample numbers: one sample is 95.24% accurate; two samples reach 96.93%; three samples reach 98.8%; four samples reach 98.81%, and finally, five samples reach 100% accuracy.
Conclusion:
the resection of three fragments was sufficient for a satisfactory result.
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