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Published on: November 4, 2017
Kinematic and electromyographic tools for characterizing movement disorders in mice
Hans C Scholle1, H A Jinnah, Dirk Arnold
1Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany.
Summary
This study uses high-speed video and electromyography (EMG) to analyze movement disorders in tottering mice. The findings reveal distinct EMG patterns for ataxia and dystonia, aiding in the study of these neurological conditions.
Area of Science:
- Neuroscience
- Movement Disorders Research
- Animal Models
Background:
- Growing interest in rodent models for movement disorders necessitates precise analysis tools.
- Tottering mutant mice exhibit both ataxia and paroxysmal dystonia, offering a unique model.
Purpose of the Study:
- To apply simultaneous high-speed video kinematics and multichannel electromyography (EMG) to characterize movement disorders in tottering mutant mice.
- To delineate the nature and severity of abnormal movements in these mice.
- To compare findings in mice with similar human movement disorders.
Main Methods:
- Simultaneous high-speed video kinematics and multichannel electromyography (EMG).
- Characterization of motor phenotype in tottering mutant mice.
- Analysis of baseline ataxia and paroxysmal dystonia episodes.
Main Results:
- Ataxic tottering mice showed uncoordinated movements, altered stance/swing times, and slower walking.
- EMG revealed reduced muscle amplitudes and poor modulation during walking.
- Dystonic attacks were preceded by specific EMG burst patterns in leg muscles.
Conclusions:
- The combined kinematic and EMG approach accurately characterizes the motor phenotype of tottering mice.
- EMG signatures correlate with clinical observations of ataxia and dystonia.
- This methodology provides insights for studying and comparing mouse and human movement disorders.
