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Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia

Josefin Ahnström1, Anders Gottsäter, Bengt Lindblad

  • 1Lund University, Department of Laboratory Medicine, Division of Clinical Chemistry, Wallenberg laboratory, entrance 46, floor 6, University Hospital, Malmö, S-20502 Malmö, Sweden.

Clinical Biochemistry
|January 19, 2010
PubMed

Insights

Apolipoprotein A-I (apoA-I) levels are lower in critical limb ischemia (CLI) patients and independently associated with the condition. This study examined apolipoproteins in CLI pathogenesis.

Area of Science:

  • Cardiovascular Research
  • Atherosclerosis Pathogenesis
  • Biomarker Discovery

Background:

  • Apolipoproteins play a role in atherosclerosis development.
  • The specific involvement of apolipoproteins in critical limb ischemia (CLI) pathogenesis remains underexplored.
  • CLI represents a severe manifestation of atherosclerosis.

Purpose of the Study:

  • To investigate the association between apolipoprotein levels and CLI.
  • To examine the role of apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), and apolipoprotein M (apoM) in CLI.
  • To determine if apolipoprotein levels are independent predictors of CLI.

Main Methods:

  • Plasma concentrations of apoA-I, apoB, and apoM were quantified.
  • Measurements were performed in 196 individuals with CLI and 214 control subjects.
  • Multivariate analyses were conducted to assess independent associations.

Main Results:

  • CLI patients exhibited significantly lower plasma levels of apoA-I, apoB, and apoM compared to controls (p<0.0001 for all).
  • ApoA-I and apoM levels correlated negatively with inflammatory markers and positively with 1- and 3-year survival rates.
  • Only apoA-I demonstrated an independent association with CLI in multivariate analyses (odds ratio = 0.015).

Conclusions:

  • Plasma concentrations of apoA-I, apoB, and apoM are significantly reduced in individuals with CLI.
  • Apolipoprotein A-I is independently associated with the presence of CLI.
  • These findings highlight apoA-I as a potential biomarker in CLI.
Abstract

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