Related Experiment Video
Updated: Jun 17, 2026

Extraction and Analysis of Taiwanese Green Propolis
Published on: January 7, 2019
Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats
Rucha Pandit1, Ashish Phadke, Aarti Jagtap
1Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, India. rucha_pan@rediffmail.com
Aims Of Study:
In Indian traditional system of medicine, Ficus religiosa (Family Moraceae) is prescribed for the treatment of diabetes mellitus. In the present study, the antidiabetic effect of aqueous extract of Ficus religiosa bark (FRAE) was investigated in normal, glucose-loaded hyperglycemic and streptozotocin (STZ)-induced diabetic rats.
Materials And Methods:
Oral administration of FRAE at the doses of 25, 50 and 100mg/kg was studied in normal, glucose-loaded and STZ-diabetic rats.
Results:
The three doses caused significant reduction in blood glucose levels in all the models. The effect was more pronounced in 50 and 100mg/kg than 25mg/kg. FRAE also showed significant increase in serum insulin, body weight and glycogen content in liver and skeletal muscle of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. FRAE also showed significant antilipidperoxidative effect in the pancreas of STZ-induced diabetic rats. The antidiabetic effect of Ficus religiosa was compared with glibenclamide, a well-known hypoglycemic drug.
Conclusion:
The results indicate that aqueous extract of Ficus religiosa bark possesses significant antidiabetic activity.
Related Concept Videos
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Biguanides and Glitazones
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Oral Hypoglycemic Agents: Sulfonylureas
