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Hypertriglyceridemia with increased plasma insulin concentrations in cats
1School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Research in Veterinary Science
|January 19, 2010
Summary
A new criterion for feline hypertriglyceridemia (hyper-TG) with increased insulin identifies early lipid metabolism issues. This helps diagnose obesity and related abnormalities in cats.
Area of Science:
- Veterinary Medicine
- Metabolic Disorders
- Companion Animal Health
Background:
- Lipid metabolism abnormalities, including obesity, are common in cats.
- Early diagnosis is crucial for effective management and prevention of secondary complications.
- Current diagnostic criteria may not fully capture early-stage metabolic dysfunction.
Purpose of the Study:
- To establish a new diagnostic criterion for feline hypertriglyceridemia (hyper-TG) characterized by increased plasma insulin concentrations.
- To identify key plasma biomarkers for the early diagnosis of lipid metabolism abnormalities and obesity in cats.
- To determine the prevalence of this newly defined hyper-TG condition in different age groups of cats.
Main Methods:
- Plasma samples were collected from 142 client-owned cats of various ages and breeds.
- Measurements included metabolite, insulin, and adiponectin concentrations, along with LDH, AST, and ALT activities.
- A new criterion for hyper-TG was defined as plasma triglyceride (TG) concentrations over 165 mg/dL with increased plasma insulin.
Main Results:
- The prevalence of hyper-TG was 16.7% in young cats (1-6 years) and 18.3% in older cats (>7 years).
- Hyper-TG cats exhibited 6.6-7.4-fold higher plasma TG concentrations compared to controls.
- Significant increases in plasma cholesterol, FFA, insulin, LDH, and ALT, and a significant decrease in adiponectin were observed in hyper-TG cats.
Conclusions:
- The new criterion of hypertriglyceridemia with increased insulin aids in the early diagnosis of lipid metabolism abnormalities in cats.
- Increased plasma TG, insulin, LDH, and ALT, coupled with decreased adiponectin, are key indicators for early detection.
- Hyper-TG cats showed signs consistent with early-stage obesity, characterized by elevated insulin and reduced adiponectin levels.
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