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Related Experiment Video

Updated: Jun 17, 2026

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

Gabapentin for smoking cessation.

Amit Sood¹, Jon O Ebbert, Kirk D Wyatt

¹Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco

|January 19, 2010

Summary

This summary is machine-generated.

This study found gabapentin ineffective for smoking cessation. High dropout rates and lower abstinence rates in the gabapentin group suggest it is not a promising treatment for tobacco dependence.

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Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

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Last Updated: Jun 17, 2026

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

Area of Science:

Pharmacology
Addiction Medicine
Clinical Trials

Background:

Tobacco dependence is a significant public health issue.
Existing treatments for smoking cessation have limitations.
Gabapentin is an anticonvulsant medication with potential for treating substance use disorders.

Purpose of the Study:

To evaluate the efficacy of gabapentin in treating tobacco dependence.
To determine optimal dosing of gabapentin for smoking cessation.
To assess the safety and tolerability of gabapentin in smokers.

Main Methods:

A randomized, double-blind, placebo-controlled trial was conducted.
Eighty participants were randomized to receive gabapentin (600 mg or 900 mg TID) or placebo.
Treatment involved a 2-week titration, 9 weeks of maintenance, and a 1-week taper, followed by 12 weeks of follow-up.

Main Results:

High dropout rates were observed in all treatment arms.
Gabapentin groups showed lower abstinence rates than placebo, though not statistically significant.
Significant smoking reduction from baseline occurred across all groups, but without inter-group differences.

Conclusions:

Gabapentin at the tested doses and regimen appears unpromising for treating tobacco dependence.
Further research with different dosing strategies or populations may be warranted.
High dropout rates indicate potential tolerability or adherence issues with gabapentin treatment.