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Holoprosencephaly: A mythologic and teratologic distillate
1Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. mmichael.cohenjr@gmail.com
Summary
Holoprosencephaly, a congenital condition, is explored through its historical and mythological representations. This review traces the concept from ancient myths to modern teratology, offering a unique perspective on its enduring presence in human understanding.
Area of Science:
- Developmental Biology
- Medical History
- Teratology
Background:
- Holoprosencephaly (HPE) is a complex congenital brain malformation.
- Understanding HPE requires examining its historical and cultural context.
- Previous reviews have focused on clinical aspects, overlooking historical narratives.
Observation:
- The review traces HPE representations from Babylonian and Greek mythology.
- Artistic depictions of HPE from the 16th to 20th centuries are analyzed.
- 19th-century teratology and modern terminologies are discussed.
Findings:
- Mythological and artistic records reveal early observations of HPE.
- The evolution of teratological concepts parallels the development of modern medicine.
- The naming of ships 'Cyclops' reflects a recurring cultural motif associated with HPE.
Implications:
- Connecting mythology, art, and teratology provides a richer understanding of HPE.
- This historical perspective can inform contemporary research and clinical approaches.
- Recognizing the long-standing presence of HPE in human culture aids in destigmatization.
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