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Preliminary evaluation of a combined microPET-MR system.
R C Hawkes1, T D Fryer, S Siegel
1Wolfson Brain Imaging Centre University of Cambridge Box 65, Addenbrookes Hospital Cambridge CB2 2QQ, UK.
Technology in Cancer Research & Treatment
|January 20, 2010
Summary
Simultaneously acquired magnetic resonance (MR) and positron emission tomography (PET) imaging offers superior image registration and motion correction. This novel system design overcomes engineering challenges for enhanced preclinical and clinical applications.
Area of Science:
- Medical Imaging
- Biophysics
- Radiological Sciences
Background:
- Simultaneous MR-PET imaging presents advantages like improved image registration, morphological detail, and reduced anesthesia time in preclinical studies.
- It offers accurate motion correction for PET image reconstruction and enables functional imaging in the same physiological state, crucial for studies like acute stroke.
- Replacing CT with MR in PET scans eliminates additional radiation, a significant benefit for cancer screening.
Purpose of the Study:
- To describe and evaluate a novel system for simultaneous positron emission tomography (PET) and magnetic resonance (MR) imaging.
- To address engineering challenges posed by combining PET and MR technologies, particularly the magnetic field's effect on photomultiplier tubes (PMTs).
Main Methods:
- A microPET Focus-120 was integrated into a 1T split magnet system.
- Magnetic-sensitive components (PMTs) were relocated to low-field regions, with PET components (scintillator blocks) remaining in the high-field area.
- Optical fibers were used to couple crystals to PMTs, and PET electronics were moved away from MR coils to mitigate electromagnetic interference.
Main Results:
- The system design successfully separated incompatible components, allowing for simultaneous PET and MR data acquisition.
- Preliminary evaluation of the integrated microPET-Focus-120 in a split magnet system was performed.
- Performance was compared to previous microPET instruments.
Conclusions:
- The developed split-magnet system enables simultaneous MR-PET imaging, overcoming key engineering hurdles.
- This approach facilitates improved image quality, motion correction, and reduced scan times.
- The system holds promise for enhanced preclinical research and clinical applications, including cancer screening and acute stroke studies.
